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Eur J Intern Med. 2008 Mar;19(2):137-9. doi: 10.1016/j.ejim.2007.03.020. Epub 2007 Sep 14.

Limitations of the QuantiFERON-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients.

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1
Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. mads.hornum@rh.dk

Abstract

Four cases are presented, immunosuppressed by at least three different mechanisms: one HIV-positive patient with a CD4 count of 0.29 x 10(6)/ml, one malnourished patient, and two kidney-transplanted patients. All patients had a negative interferon (IFN)-gamma test for suspected tuberculosis (TB), but a positive culture. We conclude that a negative IFN-gamma test does not exclude TB disease in immunosuppressed patients.

PMID:
18249311
DOI:
10.1016/j.ejim.2007.03.020
[Indexed for MEDLINE]
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