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Vet Clin North Am Small Anim Pract. 2008 Jan;38(1):137-55, vi. doi: 10.1016/j.cvsm.2007.10.004.

Mitochondrial pathophysiology, reactive oxygen species, and cardiovascular diseases.

Author information

1
Division of Molecular Medicine, Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. lcai@mednet.ucla.edu

Abstract

This article discusses mitochondrial pathophysiology, reactive oxygen species, and cardiovascular diseases. Mitochondrial respiratory chains are responsible for energy metabolism/ATP production through the tricyclic antidepressant cycle, coupling of oxidative phosphorylation, and electron transfer. The mitochondrion produces reactive oxygen species as "side products" of respiration. The mitochondrial derived reactive oxygen species is involved in the pathogenesis of various clinical disorders including heart failure, hypoxia, ischemia/reperfusion injury, diabetes, neurodegenerative diseases, and the physiologic process of aging. Observational and mechanistical studies of these pathologic roles of mitochondria are discussed in depth in this article.

PMID:
18249246
PMCID:
PMC2700041
DOI:
10.1016/j.cvsm.2007.10.004
[Indexed for MEDLINE]
Free PMC Article

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