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Cell Metab. 2008 Feb;7(2):101-3. doi: 10.1016/j.cmet.2008.01.004.

Phosphatases at the heart of FoxO metabolic control.

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1
McGill Cancer Centre, McGill University, Montréal, PQ, H3G 1Y6, Canada. michel.tremblay@mcgill.ca <michel.tremblay@mcgill.ca>

Abstract

FoxO transcription factors contribute to cardiac muscle remodeling and insulin signaling, but how they link insulin resistance and maladaptive heart hypertrophy remains unknown. A new study by Ni et al. (2007) shows that sustained activation of FoxO1 or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling through inhibition of calcineurin and PP2A.

PMID:
18249169
DOI:
10.1016/j.cmet.2008.01.004
[Indexed for MEDLINE]
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