Format

Send to

Choose Destination
Cell Metab. 2008 Feb;7(2):95-6. doi: 10.1016/j.cmet.2007.12.009.

Selective versus total insulin resistance: a pathogenic paradox.

Author information

1
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. mike.brown@utsouthwestern.edu <mike.brown@utsouthwestern.edu>

Abstract

Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia-a state paradoxically less severe than selective insulin resistance.

PMID:
18249166
DOI:
10.1016/j.cmet.2007.12.009
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center