Format

Send to

Choose Destination
Curr Opin Cell Biol. 2008 Feb;20(1):77-84. doi: 10.1016/j.ceb.2007.11.008. Epub 2008 Jan 30.

Polo and Aurora kinases: lessons derived from chemical biology.

Author information

1
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Manchester, UK. stephen.taylor@manchester.ac.uk

Abstract

During the cell division cycle, mitotic entry, spindle assembly, chromosome segregation, and cytokinesis must all be carefully coordinated to ensure that the two daughter cells inherit all the genetic material required for further growth and development. Central to this coordination are several protein kinases including Aurora A, Aurora B, and the Polo-like kinase, Plk1. A number of small-molecule Aurora and Plk1 inhibitors have been developed because these kinases are seen as attractive anticancer drug targets. These inhibitors are now being widely used as chemical biology tools to understand how these kinases ensure faithful genome transmission.

PMID:
18249108
DOI:
10.1016/j.ceb.2007.11.008
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center