Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2008 Feb 1;18(3):901-7. doi: 10.1016/j.bmcl.2007.12.066. Epub 2008 Jan 3.

New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems.

Author information

1
GlaxoSmithKline, Psychiatry Centre of Excellence for Drug Discovery, Via Fleming, 4, 37135 Verona, Italy. fm20244@gsk.com

Abstract

The synthesis and SAR of a new series of potent and selective dopamine D(3) receptor antagonists is reported. The introduction of a tricyclic [h]-fused benzazepine moiety on the recently disclosed scaffold of 1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines is reported. A full rat pharmacokinetic characterization is also reported.

PMID:
18248991
DOI:
10.1016/j.bmcl.2007.12.066
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center