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Diagn Microbiol Infect Dis. 2008 Apr;60(4):441-4. doi: 10.1016/j.diagmicrobio.2007.11.011. Epub 2008 Jan 14.

Evaluation of daptomycin, telavancin, teicoplanin, and vancomycin activity in the presence of albumin or serum.

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Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.


We evaluated the calculated protein binding based on arithmetic means of MIC values in the presence and absence of protein for daptomycin, telavancin, vancomycin, and teicoplanin against 5 Staphylococcus aureus isolates. The extent of protein binding was lower than expected, particularly for daptomycin and telavancin. These drugs may be more active than predicted based on unbound drug concentrations alone.

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