Abstract
The currently used pertussis vaccines are highly efficacious; however, neonates are susceptible to whooping cough up to the sixth month. In agreement, DTP-immunized neonate mice were not protected against intracerebral challenge with Bordetella pertussis. Neonate mice immunized with either DTP or a recombinant-BCG strain expressing the genetically detoxified S1 subunit of pertussis toxin do not show a humoral immune response against PT. On the other hand, rBCG-Pertussis induces higher PT-specific IFN-gamma production and an increase in both IFN-gamma(+) and TNF-alpha(+)-CD4(+)-T cells than the whole cell pertussis vaccine and confers protection against a lethal intracerebral challenge with B. pertussis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Bacterial / blood
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Bordetella pertussis / genetics
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Bordetella pertussis / immunology*
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CD4-Positive T-Lymphocytes / immunology
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Diphtheria-Tetanus-Pertussis Vaccine / immunology
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Humans
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Infant, Newborn
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Interferon-gamma / biosynthesis
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Mice
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Mycobacterium bovis / genetics*
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Pertussis Toxin / genetics
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Pertussis Toxin / immunology*
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Pertussis Vaccine / genetics
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Pertussis Vaccine / immunology*
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Survival Analysis
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Tumor Necrosis Factor-alpha / biosynthesis
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Whooping Cough / immunology
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Whooping Cough / prevention & control*
Substances
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Antibodies, Bacterial
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Diphtheria-Tetanus-Pertussis Vaccine
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Pertussis Vaccine
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Tumor Necrosis Factor-alpha
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pertussis toxin, S1 subunit
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Interferon-gamma
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Pertussis Toxin