Format

Send to

Choose Destination
See comment in PubMed Commons below
Chem Senses. 2008 Apr;33(4):319-29. doi: 10.1093/chemse/bjm092. Epub 2008 Feb 2.

A genome-wide screen for hyposmia susceptibility Loci.

Author information

  • 1Section of Otolaryngology-Head and Neck Surgery, The University of Chicago, 5841 S. Maryland Avenue, MC 1035, Chicago, IL 60637, USA. jpinto@surgery.bsd.uchicago.edu

Abstract

Olfactory dysfunction is an important public health problem in the United States, with approximately 14 million elderly Americans having chronic olfactory impairment. We performed a genome-wide linkage scan for loci influencing susceptibility to hyposmia in the Hutterites, a founder population of European ancestry. Using interviews regarding the olfactory medical history and psychophysical smell testing, we identified 25 individuals with severe hyposmia. Elimination of subjects with confounding conditions yielded 7 hyposmics for analysis. A 52-member pedigree including all affected individuals was constructed from the larger, >1623-member pedigree, and a genome-wide screen for loci influencing the trait of hyposmia using 1123 markers was performed. The most significant evidence for linkage with hyposmia extended over a 45 cM region on chromosome 4q (P = 0.0013). Although this signal meets the criteria for suggestive linkage only and will require replication, these results offer the strongest data to date on the effects of genetic variation on olfactory dysfunction.

PMID:
18245794
DOI:
10.1093/chemse/bjm092
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center