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Clin Cancer Res. 2008 Feb 1;14(3):627-32. doi: 10.1158/1078-0432.CCR-07-2220.

Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention.

Author information

  • 1Department of Microbiology and Cancer Center, University of Virginia Health System, Charlottesville, Virginia 22908, USA jtp@virginia.edu

Abstract

The tumor microenvironment plays a central role in cancer progression and metastasis. Within this environment, cancer cells respond to a host of signals including growth factors and chemotactic factors, as well as signals from adjacent cells, cells in the surrounding stroma, and signals from the extracellular matrix. Targeting the pathways that mediate many of these signals has been a major goal in the effort to develop therapeutics.

PMID:
18245520
DOI:
10.1158/1078-0432.CCR-07-2220
[PubMed - indexed for MEDLINE]
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