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Cereb Cortex. 2008 Aug;18(8):1923-32. doi: 10.1093/cercor/bhm220. Epub 2008 Jan 31.

Common neural substrates for inhibition of spoken and manual responses.

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1
FPR-UCLA Center for Culture, Brain and Development, University of California, Los Angeles, CA 90095-1563, USA.

Abstract

The inhibition of speech acts is a critical aspect of human executive control over thought and action, but its neural underpinnings are poorly understood. Using functional magnetic resonance imaging and the stop-signal paradigm, we examined the neural correlates of speech control in comparison to manual motor control. Initiation of a verbal response activated left inferior frontal cortex (IFC: Broca's area). Successful inhibition of speech (naming of letters or pseudowords) engaged a region of right IFC (including pars opercularis and anterior insular cortex) as well as presupplementary motor area (pre-SMA); these regions were also activated by successful inhibition of a hand response (i.e., a button press). Moreover, the speed with which subjects inhibited their responses, stop-signal reaction time, was significantly correlated between speech and manual inhibition tasks. These findings suggest a functional dissociation of left and right IFC in initiating versus inhibiting vocal responses, and that manual responses and speech acts share a common inhibitory mechanism localized in the right IFC and pre-SMA.

PMID:
18245044
DOI:
10.1093/cercor/bhm220
[Indexed for MEDLINE]
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