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Int J Biol Macromol. 2008 May 1;42(4):324-34. doi: 10.1016/j.ijbiomac.2007.12.004. Epub 2007 Dec 25.

Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes.

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Department of Oral Biochemistry and Craniomaxillofacial Reconstructive Science, Dental Research Institute, and BK21 CLS, Seoul National University School of Dentistry, 28 Yeonkun-Dong, Chongno-Ku, Seoul 110-749, Republic of Korea.


To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds.

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