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FEBS Lett. 2008 Mar 5;582(5):579-85. doi: 10.1016/j.febslet.2008.01.022. Epub 2008 Feb 1.

Serum amyloid A-induced IL-6 production by rheumatoid synoviocytes.

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1
Clinical Research Center and Department of Rheumatology, NHO Nagasaki Medical Center, Omura, Japan.

Abstract

In this study, we investigated the role of serum amyloid A protein (SAA) in the production of interleukin-6 (IL-6) using rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Recombinant SAA stimulation induced the production of pro-inflammatory cytokine, IL-6, from RA-FLS. The signaling events induced by SAA included the activation of the mitogen-activated protein kineases, p38 and JNK1/2 and the activation of nuclear factor-kappa B (NF-kappaB). Inhibitor studies have shown SAA-induced IL-6 production to be down-regulated by NF-kappaB inhibition and partially inhibited by p38 or JNK inhibitors. Our findings demonstrate that SAA is a significant inducer of IL-6, which is critically involved in RA pathogenesis.

PMID:
18243142
DOI:
10.1016/j.febslet.2008.01.022
[Indexed for MEDLINE]
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