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Mutat Res. 2008 Apr 2;640(1-2):74-81. doi: 10.1016/j.mrfmmm.2007.12.006. Epub 2007 Dec 23.

Interleukin 8 exhibits a pro-mitogenic and pro-survival role in radiation induced genomically unstable cells.

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1
Radiation Oncology Research Laboratory, 655 West Baltimore Street, Bressler Research Building, Room 7-002, University of Maryland School of Medicine, Baltimore, MD 21201, United States. elaiakis@gmail.com

Abstract

Radiation induced genomic instability can be perpetuated over time by the transmission of soluble factors. This can occur via cell-to-cell gap junction communication or the secretion/shedding of soluble factors. We have investigated whether our radiation induced chromosomally unstable GM10115 human-hamster hybrid clones secrete factors that can perpetuate the instability phenotype over time. These clones do not have functional gap junctions, but do secrete significant amounts of Interleukin 8 (IL-8) into the culture medium. We then determined whether IL-8 could initiate and or perpetuate genomic instability over time in parental GM10115 cells. Contrary to our hypothesis, IL-8 could induce DNA damage, but was not responsible for the unstable phenotype. Instead it appears that IL-8 secretion provides a pro-survival function in cells that are chromosomally unstable and generally fail to thrive.

PMID:
18242642
DOI:
10.1016/j.mrfmmm.2007.12.006
[Indexed for MEDLINE]
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