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Mutat Res. 2008 Apr 2;640(1-2):74-81. doi: 10.1016/j.mrfmmm.2007.12.006. Epub 2007 Dec 23.

Interleukin 8 exhibits a pro-mitogenic and pro-survival role in radiation induced genomically unstable cells.

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Radiation Oncology Research Laboratory, 655 West Baltimore Street, Bressler Research Building, Room 7-002, University of Maryland School of Medicine, Baltimore, MD 21201, United States.


Radiation induced genomic instability can be perpetuated over time by the transmission of soluble factors. This can occur via cell-to-cell gap junction communication or the secretion/shedding of soluble factors. We have investigated whether our radiation induced chromosomally unstable GM10115 human-hamster hybrid clones secrete factors that can perpetuate the instability phenotype over time. These clones do not have functional gap junctions, but do secrete significant amounts of Interleukin 8 (IL-8) into the culture medium. We then determined whether IL-8 could initiate and or perpetuate genomic instability over time in parental GM10115 cells. Contrary to our hypothesis, IL-8 could induce DNA damage, but was not responsible for the unstable phenotype. Instead it appears that IL-8 secretion provides a pro-survival function in cells that are chromosomally unstable and generally fail to thrive.

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