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J Calif Dent Assoc. 2007 Dec;35(12):844-9.

DNA promoter hypermethylation in saliva for the early diagnosis of oral cancer.

Author information

1
University of California, San Francisco, School of Dentistry, USA. chi.viet@ucsf.edu

Abstract

Oral health care professionals could drastically improve the quality of life for patients with potentially malignant oral lesions by using a noninvasive test that could be used to detect cancer using saliva. Promoter DNA hypermethylation is a critical step in oral carcinogenesis and has a number of significant advantages over genetic and protein diagnostic markers. Methylight is a recently developed assay that rapidly quantifies promoter hypermethylation and could potentially be applied into a clinical setting.

PMID:
18240747
[Indexed for MEDLINE]

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