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World J Gastroenterol. 2008 Feb 14;14(6):908-12.

H pylori eradication: a randomized prospective study of triple therapy with or without ecabet sodium.

Author information

1
Department of Internal Medicine, Bongseng Memorial Hospital, Busan, Korea.

Abstract

AIM:

To investigate whether adding ecabet sodium to the standard triple therapy for H pylori infection improve eradication rate.

METHODS:

Two hundred and fifty-seven H pylori-infected patients were randomly assigned to standard triple therapy (group A, n = 129) or triple therapy plus ecabet sodium (group B, n = 128). Successful eradication was defined as a negative (13)C-urea breath test 6-8 wk after completion of treatment.

RESULTS:

After completion of therapy, 194/257 patients showed negative (13)C-urea breath test results. According to intention-to-treat analysis, the infection was eradicated in 93/129 (72.1%) patients in group A and 101/128 (78.9%) in group B (P = 0.204). Per-protocol analysis showed successful eradication in 93/118 (78.8%) patients from group A and 101/114 (88.6%) from group B (P = 0.044). There were no significant differences in the side effects experienced by the patients in the two treatment groups.

CONCLUSION:

Our results suggest that the addition of ecabet sodium improves the efficacy of the standard triple therapy for H pylori.

PMID:
18240348
PMCID:
PMC2687058
DOI:
10.3748/wjg.14.908
[Indexed for MEDLINE]
Free PMC Article

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