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J Clin Immunol. 2008 Jul;28(4):285-90. doi: 10.1007/s10875-008-9170-y. Epub 2008 Feb 1.

Antibodies to mitotic spindle apparatus: clinical significance of NuMA and HsEg5 autoantibodies.

Author information

1
Department of Immunology, Hospital Universitario Central de Asturias, Celestino Villamil s/n, 33006 Oviedo, Spain. lourdes.mozo@sespa.princast.es

Abstract

INTRODUCTION:

The clinical associations of NuMA and HsEg5 antibodies, the main anti-mitotic spindle apparatus autoantibodies, remain unclear due to their extremely low prevalence.

PATIENTS AND METHODS:

We have analysed the clinical data of 40 anti-NuMA- (0.87 per thousand) and 7 anti-HsEg5- (0.15 per thousand) positive patients detected during routine immunofluorescence examination of 45,804 sera. NuMA reactivity was further confirmed by immunoblotting.

RESULTS:

Antibodies to HsEg5 did not associate with any specific pathology. NuMA positivity associated with a diagnosis of connective tissue disease (CTD) in 18 patients (45%), primary Sjögren or sicca syndrome and undifferentiated connective tissue disease being the most represented. Seven patients (17.5%) were diagnosed with different organ-specific autoimmune diseases, whereas in the other 15 patients (37.5%), no autoimmune pathology could be documented.

CONCLUSIONS:

Therefore, although both anti-mitotic spindle apparatus antibodies are not associated to a defined autoimmune pathology, the presence of NuMA antibodies, mainly at high titers, may be an indication for a more extensive screening of CTD.

PMID:
18240009
DOI:
10.1007/s10875-008-9170-y
[Indexed for MEDLINE]

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