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Obesity (Silver Spring). 2008 Feb;16(2):409-14. doi: 10.1038/oby.2007.72.

Physical inactivity and obesity: a vicious circle.

Author information

1
Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland. kirsi.pietilainen@helsinki.fi

Abstract

OBJECTIVE:

Physical activity (PA) begins to decline in adolescence with a concomitant increase in weight. We hypothesized that a vicious circle may arise between decreasing PA and weight gain from adolescence to early adulthood.

METHODS AND PROCEDURES:

PA and self-perceived physical fitness assessed in adolescents (16-18 years of age) were used to predict the development of obesity (BMI > or =30 kg/m(2)) and abdominal obesity (waist >/=88 cm in females and > or =102 cm in males) at age 25 in 4,240 twin individuals (90% of twins born in Finland, 1975-1979). Ten 25-year-old monozygotic (MZ) twin pairs who were discordant for obesity (with a 16 kg weight difference) were then carefully evaluated for current PA (using a triaxial accelerometer), total energy expenditure (TEE, assessed by means of the doubly labeled water (DLW) method), and basal metabolic rate (BMR, assessed by indirect calorimetry).

RESULTS:

Physical inactivity in adolescence strongly predicted the risk for obesity (odds ratio (OR) 3.9, 95% confidence interval (CI) 1.4-10.9) and abdominal obesity (4.8, 1.9-12.0) at age 25, even after adjusting for baseline and current BMI. Poor physical fitness in adolescence also increased the risk for overall obesity (5.1, 2.0-12.7) and abdominal obesity (3.2, 1.5-6.7) in adulthood. Physical inactivity was both causative and secondary to the development of obesity discordance in the MZ pairs. TEE did not differ between the MZ co-twins. PA was lower whereas BMR was higher in the obese co-twins.

DISCUSSION:

Physical inactivity in adolescence strongly and independently predicts total (and especially) abdominal obesity in young adulthood, favoring the development of a self-perpetuating vicious circle of obesity and physical inactivity. Physical activity should therefore be seriously recommended for obesity prevention in the young.

PMID:
18239652
PMCID:
PMC2249563
DOI:
10.1038/oby.2007.72
[Indexed for MEDLINE]
Free PMC Article

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