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Eur J Drug Metab Pharmacokinet. 1991 Oct-Dec;16(4):257-60.

Metabolism of carvedilol in man.

Author information

1
Department of Clinical Pharmacology, Boehringer Mannheim GmbH, Germany.

Abstract

The metabolism of carvedilol was investigated in plasma and urine of 3 healthy male volunteers after administration of 50 mg of [14C]-labelled drug. Rapid and extensive biotransformation occurred. After 1.5 h 9% of total radioactivity in plasma consisted of unchanged drug, 22% of carvedilol-glucuronide and another 20% of oxidative cleavage products of the beta-blocking side chain. Urinary excretion of radioactivity amounted to 16% of which 2% represented unchanged drug, 32% carvedilol-glucuronide and about 25% side chain oxidation products. Ring-hydroxylated metabolites of carvedilol accounted for 18% of the radioactive compounds in the urine.

PMID:
1823868
DOI:
10.1007/BF03189969
[Indexed for MEDLINE]

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