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Cancer Metastasis Rev. 2008 Jun;27(2):215-30. doi: 10.1007/s10555-008-9115-1.

PTP1B and TC-PTP: regulators of transformation and tumorigenesis.

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McGill Cancer Centre and Department of Biochemistry, McGill University, Montreal, QC, Canada.


PTP1B and T cell PTP (TC-PTP) are protein tyrosine phosphatases (PTPs) that share high sequence and structural homology yet play distinct physiological roles. While PTP1B plays a central role in metabolism and is an attractive drug target for obesity and type 2 diabetes, TC-PTP is necessary for the control of inflammation. In this review, we will discuss the growing evidence for the involvement of PTP1B in cancer, while proposing a role for TC-PTP in inflammation-induced tumorigenesis. Given the challenge of developing inhibitors specific for PTP1B alone, it is necessary to consider both enzymes and their roles in various cancer models.

[Indexed for MEDLINE]

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