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Phys Rev Lett. 2008 Jan 11;100(1):018104. Epub 2008 Jan 8.

Nonequilibrium mechanics and dynamics of motor-activated gels.

Author information

1
Department of Physics & Astronomy, Vrije Universiteit, 1081HV Amsterdam, The Netherlands. fcm@nat.vu.nl

Abstract

The mechanics of cells is strongly affected by molecular motors that generate forces in the cellular cytoskeleton. We develop a model for cytoskeletal networks driven out of equilibrium by molecular motors exerting transient contractile stresses. Using this model we show how motor activity can dramatically increase the network's bulk elastic moduli. We also show how motor binding kinetics naturally leads to enhanced low-frequency stress fluctuations that result in nonequilibrium diffusive motion within an elastic network, as seen in recent in vitro and in vivo experiments.

PMID:
18232824
DOI:
10.1103/PhysRevLett.100.018104
[Indexed for MEDLINE]

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