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Org Lett. 2008 Mar 6;10(5):1025-8. doi: 10.1021/ol800092p. Epub 2008 Jan 31.

Direct carbocyclization of aldehydes with alkynes: combining gold catalysis with aminocatalysis.

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1
Department Chemie, Technische Universit√§t M√ľnchen, Lichtenbergstrasse 4, 85747 Garching, Germany.

Abstract

A combination of gold(I) complexes and amine bases catalyzes the 5-exo-dig cyclization of formyl alkynes. This direct alpha-functionalization of aldehydes with unactivated alkynes does not involve the use of preformed enol equivalents.

PMID:
18232707
DOI:
10.1021/ol800092p
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