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Br J Cancer. 2008 Feb 26;98(4):677-83. doi: 10.1038/sj.bjc.6604209. Epub 2008 Jan 29.

Targeting telomerase for cancer therapeutics.

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1
Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9030, USA. Jerry.Shay@UTSouthwestern.edu

Abstract

One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells.

PMID:
18231105
PMCID:
PMC2259186
DOI:
10.1038/sj.bjc.6604209
[Indexed for MEDLINE]
Free PMC Article
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