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Front Horm Res. 2008;36:1-11. doi: 10.1159/0000115333.

Monogenic human obesity.

Author information

  • 1Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK. isf20@cam.ac.uk

Abstract

We and others have identified several single gene defects that disrupt the molecules in the leptinmelanocortin pathway causing severe obesity in humans. In this review, we consider these human monogenic obesity syndromes and discuss how far the characterisation of these patients has informed our understanding of the physiological role of leptin and the melanocortins in the regulation of human body weight and neuroendocrine function.

PMID:
18230891
DOI:
10.1159/0000115333
[PubMed - indexed for MEDLINE]
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