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Ann Biol Clin (Paris). 2008 Jan-Feb;66(1):59-62. doi: 10.1684/abc.2008.0191.

[Detection of Epstein-Barr virus in breast cancers with lymphoid stroma].

[Article in French]

Author information

1
Laboratoire d'anatomie et de cytologie pathologiques, CHU Farhat Hached, Sousse, Tunisie. trabelsiamel@yahoo.fr <trabelsiamel@yahoo.fr>

Abstract

OBJECTIVE:

the purpose of our work is to detect Epstein-Barr virus (EBV) in 2 types of breast cancer: medullary carcinoma and high grade invasive ductal carcinoma with lymphoid stroma.

PATIENTS AND METHODS:

we proceeded to a retrospective study of 18 medullary carcinoma and 18 high grade invasive ductal carcinoma with lymphoid stroma. The detection of the virus was carried out by immunohistochemistry with anti-LMP2 antibody and by hybridization in situ by oligonucleotides EBER1 and EBER1. LMP1 as well as hybridization in situ were positive in 5 tumors (3 medullary carcinoma and 2 high grade invasive ductal carcinoma with lymphoid stroma).

RESULTS:

positivity was observed in tumor cells and neither in epithelial non tumoral ones nor in lymphoid cells.

DISCUSSION AND CONCLUSIONS:

during numerous years, correlations between the replication of EBV and the appearance of a malignant phenotype were limited to nasopharyngeal carcinoma and to lymphoid cells. A controversy regarding the association of EBV with breast cancers has recently been reported in the literature. This cancer being very frequent, the involvement of EBV even in a small proportion of breast cancers could have important implications. Our results suggest a possible implication of EBV in these tumours but other studies are necessary.

PMID:
18227005
DOI:
10.1684/abc.2008.0191
[Indexed for MEDLINE]
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