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J Intern Med. 2008 Feb;263(2):128-41. doi: 10.1111/j.1365-2796.2007.01902.x.

SIRT6 in DNA repair, metabolism and ageing.

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1
Howard Hughes Medical Institute, The Children's Hospital, CBR Institute for Biomedical Research, Boston, MA, USA.

Abstract

Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and Insulin/Igf1-like signalling. In addition, homologs of yeast Sir2--the sirtuins--regulate lifespan in diverse organisms. Here, we focus on one particular sirtuin, SIRT6. Mice lacking SIRT6 develop a degenerative disorder that in some respects mimics models of accelerated ageing [Cell (2006) 124:315]. We discuss how sirtuins in general and SIRT6 specifically relate to other evolutionarily conserved pathways affecting ageing, and how SIRT6 might function to ensure organismal homeostasis and normal lifespan.

PMID:
18226091
PMCID:
PMC2486832
DOI:
10.1111/j.1365-2796.2007.01902.x
[Indexed for MEDLINE]
Free PMC Article
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