Antithrombotic activity of heparin-ATP complex

Bull Exp Biol Med. 2007 Mar;143(3):299-301. doi: 10.1007/s10517-007-0094-y.

Abstract

The complex of high-molecular-weight heparin and ATP prevented thrombus formation in the blood flow. Repeated intramuscular injection of the complex increased total fibrinolytic activity of the blood, nonenzymatic fibrinolysis, and plasma anticoagulant activity and significantly decreased platelet aggregation.

MeSH terms

  • Adenosine Triphosphate / administration & dosage
  • Adenosine Triphosphate / chemistry
  • Adenosine Triphosphate / pharmacology*
  • Animals
  • Fibrinolysis / drug effects
  • Fibrinolytic Agents / administration & dosage
  • Fibrinolytic Agents / chemistry
  • Fibrinolytic Agents / pharmacology*
  • Heparin / administration & dosage
  • Heparin / chemistry
  • Heparin / pharmacology*
  • Injections, Intramuscular
  • Macromolecular Substances
  • Male
  • Platelet Aggregation / drug effects
  • Rats
  • Thrombosis / prevention & control

Substances

  • Fibrinolytic Agents
  • Macromolecular Substances
  • Adenosine Triphosphate
  • Heparin