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Curr Opin Genet Dev. 1991 Aug;1(2):230-5.

Axon guidance in the vertebrate central nervous system.

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Division of Anatomy and Cell Biology, United Medical School, Guy's Hospital, London, UK.


The development of connections in the central nervous system depends on the ability of the tips of growing axons to find their appropriate, often distant, target field. Factors that regulate axon outgrowth may be distinct from those that influence direction finding. Tissue culture methods have helped to distinguish between possible in vivo mechanisms and, in some cases, have identified candidate molecules.

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