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Fertil Steril. 2008 Oct;90(4):1290-3. doi: 10.1016/j.fertnstert.2007.10.081. Epub 2008 Jan 28.

Transient receptor potential vanilloid receptor-1 confers heat resistance to male germ cells.

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Fertility Laboratory, Center for Reproductive Medicine, Academic Medical Center, Amsterdam, The Netherlands.


Testicular hyperthermia in mice lacking transient receptor potential vanilloid receptor-1 results in a much more rapid and massive germ cell depletion from the seminiferous tubules than in wild-type animals, indicating that this receptor protects germ cells against heat stress.

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