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Aging Cell. 2008 Mar;7(2):250-9. doi: 10.1111/j.1474-9726.2008.00372.x. Epub 2008 Jan 21.

Epidermal stem cells are retained in vivo throughout skin aging.

Author information

1
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK. adam.giangreco@cancer.org.uk

Abstract

In healthy individuals, skin integrity is maintained by epidermal stem cells which self-renew and generate daughter cells that undergo terminal differentiation. It is currently unknown whether epidermal stem cells influence or are affected by skin aging. We therefore compared young and aged skin stem cell abundance, organization, and proliferation. We discovered that despite age-associated differences in epidermal proliferation, dermal thickness, follicle patterning, and immune cell abundance, epidermal stem cells were maintained at normal levels throughout life. These findings, coupled with observed dermal gene expression changes, suggest that epidermal stem cells themselves are intrinsically aging resistant and that local environmental or systemic factors modulate skin aging.

PMID:
18221414
PMCID:
PMC2339763
DOI:
10.1111/j.1474-9726.2008.00372.x
[Indexed for MEDLINE]
Free PMC Article

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