Format

Send to

Choose Destination
Mini Rev Med Chem. 2008 Jan;8(1):24-35.

Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.

Author information

1
Institut Gilbert Laustriat, Photophysique des interactions moléculaires, UMR 7175 CNRS, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg 1, 74, Route du Rhin, 67401 ILLKIRCH Cedex, France.

Abstract

The nucleocapsid protein (NC) plays seminal roles in HIV replication, thus representing a major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc ejectors inhibit NC functions, but with limited specificity. New classes of molecules competing with NC or its viral nucleic acid and enzyme partners are reviewed here.

PMID:
18220982
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Bentham Science Publishers Ltd.
Loading ...
Support Center