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Mini Rev Med Chem. 2007 Dec;7(12):1248-54.

Tetraspanins-structural and signalling scaffolds that regulate platelet function.

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Immunoreceptor Laboratory, Burnet Institute at Austin, Studley Road, Heidelberg, Victoria 3084, Australia.


There are several tetraspanins present in platelets including CD9, CD151, TSSC6, and CD63. Recent studies in knockout mouse models have revealed that CD151 and TSSC6 are physically and functionally involved in regulation of the 'outside-in' signalling properties of the major platelet integrin, integrin alpha(IIb)beta(3) and thrombus stability in vivo.

[Indexed for MEDLINE]

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