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Curr Alzheimer Res. 2007 Dec;4(5):541-3.

APP-based neuroprotective strategies.

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  • 1Buck Institute for Age Research and University of California, San Francisco, USA.


While much of the focus on Alzheimer's disease therapeutics has been directed at beta-amyloid peptide or at cholinergic synaptic transmission, recent data suggest that targeting signal transduction by the amyloid precursor protein (APP) itself may be an alternative approach with significant potential [1]. Here we discuss the possibility that APP-mediated signal transduction, downstream from amyloid-beta peptide production itself, may be an appropriate therapeutic target in Alzheimer's disease.

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