Abstract
Phytochemical investigation of the leaves and twigs of Taxus sumatrana afforded six new taxane diterpene esters, tasumatrols U-Z ( 1- 6). Compounds 2 and 5 contained a rare five-membered lactone ring at C-8, C-9, C-10, and C-19. The structures were established on the basis of detailed spectroscopic analyses, particularly HRESIMS and 2D NMR techniques. Compound 5 showed cytotoxicity against a human hepatoma (Hep2) cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Bridged-Ring Compounds / chemistry
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Bridged-Ring Compounds / isolation & purification*
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Bridged-Ring Compounds / pharmacology
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Esters
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Taiwan
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Taxoids / chemistry
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Taxoids / isolation & purification*
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Taxoids / pharmacology
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Taxus / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Bridged-Ring Compounds
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Diterpenes
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Esters
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Taxoids
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taxane