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J Magn Reson Imaging. 2008 Feb;27(2):299-310. doi: 10.1002/jmri.21263.

Stem cell therapy: MRI guidance and monitoring.

Author information

1
Johns Hopkins University, School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD 21287, USA. dkraitc1@jhu.edu

Abstract

With the recent advances in magnetic resonance (MR) labeling of cellular therapeutics, it is natural that interventional MRI techniques for targeting would be developed. This review provides an overview of the current methods of stem cell labeling and the challenges that are created with respect to interventional MRI administration. In particular, stem cell therapies will require specialized, MR-compatible devices as well as integration of graphical user interfaces with pulse sequences designed for interactive, real-time delivery in many organs. Specific applications that are being developed will be reviewed as well as strategies for future translation to the clinical realm.

PMID:
18219684
PMCID:
PMC3075622
DOI:
10.1002/jmri.21263
[Indexed for MEDLINE]
Free PMC Article

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