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Nat Rev Immunol. 2008 Feb;8(2):107-19. doi: 10.1038/nri2251.

Shaping and reshaping CD8+ T-cell memory.

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Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, USA.


The ability to develop and sustain populations of memory T cells after infection or immunization is a hallmark of the adaptive immune response and a basis for protective vaccination against infectious disease. Technical advances that allow direct ex vivo identification and characterization of antigen-specific CD8+ T cells at various stages of the response to infection or vaccination in mouse models have fuelled efforts to characterize the factors that control memory CD8+ T-cell generation. Here, we dissect the input signals that shape the characteristics of the memory CD8+ T-cell response and discuss how manipulation of these signals has the potential to reshape CD8+ T-cell memory and improve the efficacy of vaccination.

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