Format

Send to

Choose Destination
Nat Rev Cancer. 2008 Feb;8(2):133-40. doi: 10.1038/nrc2296.

Ral GTPases and cancer: linchpin support of the tumorigenic platform.

Author information

1
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

Abstract

A confluence of recent observations has indicted the Ras-family G-proteins RALA and RALB as key offenders in the subversion of core biological systems driving oncogenic transformation. Here, we will focus on current developments highlighting the pivotal contribution of Ral proteins to the regulatory framework supporting tumorigenesis, and evaluate mechanistic connections between Ral effector activation and generation of this framework.

PMID:
18219307
DOI:
10.1038/nrc2296
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center