Abstract
Two new aporphine alkaloids, isofiliformine ( 1) and cassythic acid ( 3), along with 22 known compounds were isolated from whole herb of Cassytha filiformis. Cassythic acid ( 3), cassythine ( 4), neolitsine ( 7), and dicentrine ( 8) had potent vasorelaxing effects on precontracted rat aortic preparations with mean IC 50 values between 0.08 and 2.48 microM. Compounds 1, 1,2-methylenedioxy-3,10,11-trimethoxyaporphine ( 2), (-)- O-methylflavinatine ( 10), (-)-salutaridine ( 11), isohamnetin-3- O-beta-glucoside, and isohamnetin-3- O-rutinoside exerted moderate vessel-relaxing activities with IC 50 values from 16.50 to 32.81 microM at the test concentrations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Animals
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Aorta / drug effects
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Aporphines / chemistry
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Aporphines / isolation & purification*
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Aporphines / pharmacology*
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology*
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Inhibitory Concentration 50
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Lauraceae / chemistry*
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Male
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Molecular Structure
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Plants, Medicinal / chemistry*
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Rats
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Rats, Sprague-Dawley
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Taiwan
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Vasodilator Agents / chemistry
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Vasodilator Agents / isolation & purification*
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Vasodilator Agents / pharmacology*
Substances
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1,2-methylenedioxy-3,10,11-trimethoxyaporphine
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Alkaloids
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Aporphines
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Flavonoids
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Vasodilator Agents
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isofiliformine