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Curr Eye Res. 2008 Jan;33(1):13-8. doi: 10.1080/02713680701827696.

Effect of retinol palmitate eye drops on experimental keratoconjunctival epithelial damage induced by n-heptanol in rabbit.

Author information

1
Department of Ophthalmology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan. toshida@med.juntendo.ac.jp

Abstract

PURPOSE:

To investigate ability of vitamin A (VA, retinol palmitate) to promote wound healing after injury in rabbit eye.

METHODS:

After keratoconjunctival injury by 20 microL of n-heptanol, VA eye drops at 500, 1000, or 1500 IU/mL were started 6 times a day for 11 days. Fluorescein and rose bengal staining and histological analysis were performed.

RESULTS:

Fluorescein staining was significantly reduced by 1000 and 1500 IU/mL of VA and rose bengal staining by all concentrations. Histological examination revealed acceleration of wound healing after 7 days (1500 IU/mL).

CONCLUSIONS:

VA may be useful in treatment of keratoconjunctival injury.

PMID:
18214738
DOI:
10.1080/02713680701827696
[Indexed for MEDLINE]

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