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Bull Exp Biol Med. 2007 Apr;143(4):431-3.

Dipeptide preparation Noopept prevents scopolamine-induced deficit of spatial memory in BALB/c mice.

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1
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.

Abstract

The effect of original nootropic preparation Noopept on learning and long-term memory was studied with BALB/c mice. Scopolamine (1 mg/kg) impaired long-term memory trace, while Noopept (0.5 mg/kg) had no significant effect. Noopept completely prevented the development of cognitive disorders induced by scopolamine (blockade of muscarinic cholinergic receptors). Our results confirmed the presence of choline-positive effect in dipeptide piracetam analogue Noopept on retrieval of learned skill of finding a submerged platform (spatial memory). We conclude that the effectiveness of this drug should be evaluated in patients with Alzheimer's disease.

PMID:
18214292
[Indexed for MEDLINE]

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