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Antimicrob Agents Chemother. 2008 Apr;52(4):1556-8. doi: 10.1128/AAC.01458-07. Epub 2008 Jan 22.

Combination echinocandin-polyene treatment of murine mucormycosis.

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1
Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. ibrahim@labiomed.org

Abstract

We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.

PMID:
18212099
PMCID:
PMC2292548
DOI:
10.1128/AAC.01458-07
[Indexed for MEDLINE]
Free PMC Article
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