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Mol Cell Biol. 2008 Apr;28(7):2167-74. doi: 10.1128/MCB.01977-07. Epub 2008 Jan 22.

MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.

Author information

1
Rosetta Inpharmatics LLC, 401 Terry Ave. N, Seattle, WA 98109, USA. irena_ivanovska@merck.com

Abstract

microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas loss of function reverses this phenotype. Microarray profiling uncovers multiple targets of the family, including the cyclin-dependent kinase inhibitor p21/CDKN1A. We show that p21 is a direct target of miR-106b and that its silencing plays a key role in miR-106b-induced cell cycle phenotypes. We also show that miR-106b overrides a doxorubicin-induced DNA damage checkpoint. Thus, miR-106b family members contribute to tumor cell proliferation in part by regulating cell cycle progression and by modulating checkpoint functions.

PMID:
18212054
PMCID:
PMC2268421
DOI:
10.1128/MCB.01977-07
[Indexed for MEDLINE]
Free PMC Article

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