HLA-DR17 and Mooren's ulcer in South India

Br J Ophthalmol. 2008 Feb;92(2):179-81. doi: 10.1136/bjo.2007.127050. Epub 2008 Jan 22.

Abstract

Objective: To investigate the association between Mooren's ulcer and human leucocyte antigen (HLA) type DR17(3) in patients from the Tamil Nadu State of South India.

Methods: Blood samples from 38 patients with Mooren's ulcer and 45 age- and sex-matched controls were obtained prospectively. HLA-DR and HLA-DQ typing was performed by PCR using sequence-specific primers.

Results: Fifteen (40%) of the patients with Mooren's ulcer tested positive for HLA-DR17(3) compared with seven (16%) of the controls (p = 0.01). Seventeen (45%) of the patients also tested positive for the closely linked HLA-DQ2 compared with 11 (24%) of controls (p = 0.05). When adjusted for multiplicity, the correlation between HLA-DR17(3) and Mooren's ulcer remained significant (p = 0.03).

Conclusions: These data demonstrate an association between HLA-DR17(3) and Mooren's ulcer in South Indian patients, supporting autoimmune theories about the pathogenesis of the disorder.

MeSH terms

  • Autoimmune Diseases / immunology
  • Corneal Ulcer / immunology*
  • Female
  • HLA-DQ Antigens / blood
  • HLA-DR Antigens / blood*
  • Histocompatibility Testing / methods
  • Humans
  • Male
  • Prospective Studies

Substances

  • HLA-DQ Antigens
  • HLA-DQ2 antigen
  • HLA-DR Antigens