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Mult Scler. 2008 Apr;14(3):292-9. doi: 10.1177/1352458507083188. Epub 2008 Jan 21.

Chlamydia pneumoniae-specific serum immune complexes in patients with multiple sclerosis.

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Department of Neurology, University of Sydney, Blackburn Building, Camperdown, Sydney, NSW 2006, Australia.


The significance of Chlamydia pneumoniae infection in patients with multiple sclerosis (MS) is unclear. We determined the frequency of serum C. pneumoniae-specific immune complexes in patients with MS, neurological (OND) and healthy controls in a blinded, cross-sectional study. C. pneumoniae immune complexes were detected in 24% (38/156) of MS patients, 16% (11/69) of OND and 15% (77/499) of healthy controls. The odds ratio for all MS patients was 3.95 (95% CI: 2.15 to 7.24; P < 0.0001) accounting for the covariates: sex, age, socio-economic status and area of residence. The odds ratio for recently diagnosed MS patients was 4.33 (95% CI: 1.76 to 10.64; P = 0.001). Systemic C. pneumoniae infection is more frequent in MS patients than the healthy population and occurs early in the course of the disease.

[Indexed for MEDLINE]

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