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Biol Chem. 2008 Mar;389(3):257-65. doi: 10.1515/BC.2008.034.

Potential biomarkers of ageing.

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1
Department of Cardiothoracic Surgery, Martin LutherUniversity Halle-Wittenberg, Ernst-Grube Str. 40,D-06120 Halle, Germany. andreas.simm@medizin.uni-halle.de

Abstract

Life span in individual humans is very heterogeneous.Thus, the ageing rate, measured as the decline of functional capacity and stress resistance, is different in every individual. There have been attempts made to analyse this individual age, the so-called biological age, in comparison to chronological age. Biomarkers of ageing should help to characterise this biological age and, as age is a major risk factor in many degenerative diseases,could be subsequently used to identify individuals at high risk of developing age-associated diseases or disabilities. Markers based on oxidative stress, protein glycation,inflammation, cellular senescence and hormonal deregulation are discussed.

PMID:
18208349
DOI:
10.1515/BC.2008.034
[Indexed for MEDLINE]
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