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J Pharm Biomed Anal. 2008 Mar 13;46(4):814-7. doi: 10.1016/j.jpba.2007.12.007. Epub 2007 Dec 15.

Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac.

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  • 1National Institute for Public Health and the Environment, Postbox 1, 3720 BA, Bilthoven, The Netherlands.


A new analogue of sildenafil was detected in a herbal aphrodisiac. The structure of the compound was established using LC-MS, UV and IR spectroscopy, MS-MS, and NMR. The compound, named thio-homosildenafil is a synthetic N-ethylpiperazine analogue of sildenafil in which also the CO moiety has been converted into a CS group. This is the first time a sildenafil analogue modified at the chromophore was identified as an adulterant of a herbal aphrodisiac. Preliminary pharmacological analysis confirmed the erectogenic potency of thio-homosildenafil.

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