Format

Send to

Choose Destination
Exp Neurol. 2008 Apr;210(2):602-7. doi: 10.1016/j.expneurol.2007.12.008. Epub 2007 Dec 23.

Anti-apoptotic therapy with a Tat fusion protein protects against excitotoxic insults in vitro and in vivo.

Author information

1
Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA.

Abstract

A number of gene therapy approaches have been developed for protecting neurons from necrotic neurological insults. Such therapies are limited by the need for transcription and translation of the protective protein, delaying therapeutic impact. As an alternative, we explore the neuroprotective potential of protein therapy, using a fusion protein comprised of the death-suppressing BH4 domain of the Bcl-xL protein and the protein transduction domain of the human immunodeficiency virus Tat protein. This fusion protein decreased neurotoxicity caused by the excitotoxins glutamate and kainic acid in primary hippocampal cultures, and decreased hippocampal damage in vivo in an excitotoxic seizure model.

PMID:
18207142
PMCID:
PMC4782922
DOI:
10.1016/j.expneurol.2007.12.008
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center