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Mol Cell. 2008 Jan 18;29(1):1-7. doi: 10.1016/j.molcel.2007.12.010.

Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs.

Author information

1
Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.

Abstract

The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles remain largely unresolved.

PMID:
18206964
DOI:
10.1016/j.molcel.2007.12.010
[Indexed for MEDLINE]
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