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Trends Cardiovasc Med. 2008 Jan;18(1):20-5. doi: 10.1016/j.tcm.2007.11.002.

Vascular cytochrome p450 enzymes: physiology and pathophysiology.

Author information

1
Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe-Universität, D-60590 Frankfurt am Main, Germany. fleming@em.uni-frankfurt.de

Abstract

Cytochrome P450 epoxygenases and the soluble epoxide hydrolase are enzymes that regulate the cellular content of bioactive epoxides such as the epoxyeicosatrienoic acids derived from arachidonic acid. Epoxyeicosatrienoic acids are recognized as lipid mediators that participate in vascular signaling processes such as the acute regulation of vascular tone and the processes of inflammation and angiogenesis.

PMID:
18206805
DOI:
10.1016/j.tcm.2007.11.002
[Indexed for MEDLINE]
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