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Acta Psychiatr Scand. 2008 Apr;117(4):283-8. doi: 10.1111/j.1600-0447.2007.01142.x. Epub 2008 Jan 16.

Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder.

Author information

1
Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, Goettingen, Germany. hscherk@uni-goettingen.de

Abstract

OBJECTIVE:

Subcortical regions such as hippocampus, thalamus and ventral putamen are assumed to be involved in the pathophysiology of mood regulation. Disturbed hippocampal neuronal function indicated by reduced N-acetyl-aspartate (NAA) levels in bipolar patients was shown by several studies. Results in thalamus and putamen are inconsistent.

METHOD:

N-acetyl-aspartate, choline (Cho), creatine (Cr) and myo-inositol (Ins) were measured in left hippocampus, left thalamus and left putamen using proton magnetic resonance spectroscopy in 13 euthymic patients with bipolar I disorder and 13 pairwise matched healthy control subjects. Metabolic ratios NAA/Cr, NAA/Cho, Cho/Cr and Ins/Cr were calculated.

RESULTS:

Patients with bipolar I disorder demonstrated significantly reduced NAA/Cr in the left hippocampus compared with healthy control subjects. No alterations were found in thalamus or putamen.

CONCLUSION:

We hypothesize that this NAA/Cr reduction might reflect neuronal dysfunction in the left hippocampus in patients with bipolar disorder.

[Indexed for MEDLINE]

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